What Is Dihexa?
Dihexa (also known as PNB 0408) is an angiotensin IV derived oligopeptide that binds hepatocyte growth factor (HGF) and potentiates downstream HGF c Met signaling. In research contexts, it is discussed primarily for synaptogenesis and cognitive function endpoints in animal models of impairment, with an emphasis on its apparent brain penetration and oral activity.
Mechanisms of Action
Bind to HGF and facilitate functional activation of the HGF c Met pathway, supporting pro synaptogenic signaling
Support synaptogenesis and dendritic spine related endpoints associated with learning and memory in impaired model designs
Promote neurotrophic like downstream effects (often framed as network repair and connectivity restoration in mechanistic discussions)
Demonstrate apparent BBB penetration and metabolic stability features in preclinical pharmacokinetic work
Benefits
Improved learning and memory performance endpoints in animal models of cognitive dysfunction (not consistently seen in unimpaired models)
Increased synapse and spine density markers in hippocampal related readouts in preclinical research
Potential neurorepair oriented signaling via HGF c Met activation, which is why fosgonimeton (a prodrug approach) has been studied clinically for neurodegenerative indications
Dosing
Dosage | Frequency |
|---|---|
5-10mg | 2-3x a week |
Note: Due to how powerful this compound is on hepatocyte growth, Dihexa should be cycled on for 4 weeks with at least the same amount of time off.
Safety Profile
Dihexa has no well established long term human safety profile, and evidence is largely preclinical. A key theoretical concern discussed in the literature is that HGF c Met signaling is implicated in oncogenic biology in some contexts, which is why tumorigenesis and cancer progression risk is often raised as an uncertainty rather than a confirmed outcome.
Reported tolerability discussions commonly mention mild CNS or GI type effects as possibilities (for example restlessness, headache, or nausea), but systematic safety data remain limited and should be treated as incomplete.
Stacking
Cognitive Stack
Dihexa
Semax
Selank
NAD+
Neuroplasticity Stack
Dihexa
Cerebrolysin
Methylene Blue
NAD+
Disclaimer: The information provided is intended solely for educational purposes and should not be considered a replacement for professional medical advice. All compounds referenced are not for human consumption.
